Augmentation as a treatment complication of restless legs syndrome: Concept and management
Identifieur interne : 003003 ( Main/Exploration ); précédent : 003002; suivant : 003004Augmentation as a treatment complication of restless legs syndrome: Concept and management
Auteurs : Diego García-Borreguero [Espagne] ; Richard P. Allen [États-Unis] ; Heike Benes [Allemagne] ; Christopher Earley [États-Unis] ; Svenja Happe [Allemagne] ; Birgit Högl [Autriche] ; Ralf Kohnen [Allemagne] ; Walter Paulus [Allemagne] ; David Rye [États-Unis] ; Juliane Winkelmann [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Dopamine Agents.
- chemical , therapeutic use : Dopamine Agents.
- drug therapy : Restless Legs Syndrome.
- Disease Progression, Humans.
Abstract
Augmentation constitutes the main complication of long‐term dopaminergic treatment in restless legs syndrome (RLS). Although this condition was first described in 1996, and is characterized by an overall increase in severity of RLS symptoms (including earlier onset of symptoms during the day, faster onset of symptoms when at rest, expansion to the upper limbs and trunk, and shorter duration of the treatment effect), precise diagnostic criteria were not established until 2003. These criteria have recently been updated to form a new definition of augmentation based on multicentric studies. The present article reviews our current knowledge on clinical diagnosis, evaluation, pathophysiology, and treatment recommendations for this condition. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21610
Affiliations:
- Allemagne, Autriche, Espagne, États-Unis
- Basse-Saxe, Bavière, Communauté de Madrid, District de Haute-Bavière, Géorgie (États-Unis), Maryland
- Göttingen, Madrid, Munich
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Le document en format XML
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<term>Restless Legs Syndrome (drug therapy)</term>
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<front><div type="abstract" xml:lang="en">Augmentation constitutes the main complication of long‐term dopaminergic treatment in restless legs syndrome (RLS). Although this condition was first described in 1996, and is characterized by an overall increase in severity of RLS symptoms (including earlier onset of symptoms during the day, faster onset of symptoms when at rest, expansion to the upper limbs and trunk, and shorter duration of the treatment effect), precise diagnostic criteria were not established until 2003. These criteria have recently been updated to form a new definition of augmentation based on multicentric studies. The present article reviews our current knowledge on clinical diagnosis, evaluation, pathophysiology, and treatment recommendations for this condition. © 2007 Movement Disorder Society</div>
</front>
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